2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-124332
    25T7-NBOMe hydrochloride 1539266-55-1 98%
    25T7-NBOMe hydrochloride is a derivative of 2C-T-7, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine.
    25T7-NBOMe hydrochloride
  • HY-124341
    ND-378 1807453-72-0 98%
    ND-378 is a potent and selective inhibitor of matrix metalloproteinases (MMP-2) with a Ki value of 230 nM. ND-378 can be used to study spinal cord injury (SCI).
    ND-378
  • HY-124393
    GRN-529 1253291-12-1 98%
    GRN-529 is a negative allosteric modulator (NAM) for mGluR5. GRN-259 modulates sleep-wake activity, and exhibits anxiolytic efficacy in rats.
    GRN-529
  • HY-124474
    Procurcumenol 21698-40-8 98%
    Procurcumenol, a natural compound that can be isolated from Curcuma zedoaria Rhizomes, possesses neuroprotective and antioxidant activity. Procurcumenol can target CCR5 and has a significant inhibitory effect on platelet aggregation in vitro.
    Procurcumenol
  • HY-124491
    Moquizone 19395-58-5 98%
    Moquizone is a choleretic agent with arrhythmia-preventing activity.
    Moquizone
  • HY-124503
    Longanlactone 1438721-51-7 98%
    Longanlactone is a natural pyrrole-lactone alkaloid that can be used as a neurotrophic agent. Longanlactone increases BDNF gene expression in neuro2a cells.
    Longanlactone
  • HY-124517
    Burimamide 34970-69-9 98%
    Burimamide is a blocker of histamine H2-receptor. Burimamide inhibits gastric acid secretion evoked by Pentagastrin (HY-A0261) or Gastrin. Burimamide also has alpha-adrenoceptor blocking activity. Burimamide in combination with the H1-receptor antagonist Mepyramine (HY-B1281) shows anti-inflammatory activity in a rat paw edema model induced by Compound 48/80 (HY-115768).
    Burimamide
  • HY-124521
    Quinelorane 97466-90-5 98%
    Quinelorane (LY163502 free base) is a dopamine D2 receptor agonist. Quinelorane promotes semen ejaculation but inhibits penile erection in rats. Quinelorane can be used in the study of sexual dysfunction.
    Quinelorane
  • HY-124524
    Alentemol 112891-97-1 98%
    Alentemol (U-66444B free base) is a brain-penetrant dopamine D1-, D2-, D3-, D4- agonist. Alentemol acts on presynaptic dopamine receptors to reduce dopamine release and synthesis. Alentemol can be used for the research of schizophrenia.
    Alentemol
  • HY-12452R
    DPN (Standard) 1428-67-7
    DPN (Standard) is the analytical standard of DPN. This product is intended for research and analytical applications. DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases.
    DPN (Standard)
  • HY-12472R
    Balipodect (Standard) 1238697-26-1 98%
    Balipodect (Standard) is the analytical standard of Balipodect. This product is intended for research and analytical applications. Balipodect (TAK-063) is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.
    Balipodect (Standard)
  • HY-124925
    Vincanol 19877-89-5 98%
    Vincanol ((-)-Isoeburnamine) is a blocker of voltage-gated Na+ channels. Vincanol blocks Na+ currents with an IC50 value of 40 μM. Vincanol has neuroprotective effect.
    Vincanol
  • HY-12497R
    ANA-12 (Standard) 219766-25-3 98%
    ANA-12 (Standard) is the analytical standard of ANA-12. This product is intended for research and analytical applications. ANA-12 is a potent and selective TrkB antagonist with IC50s of 45.6 nM and 41.1 μM for the high and low affinity sites, respectively.
    ANA-12 (Standard)
  • HY-12503R
    CFM-2 (Standard) 178616-26-7
    CFM-2 (Standard) is the analytical standard of CFM-2. This product is intended for research and analytical applications. CFM-2 is a potent and selective non-competitive AMPAR antagonist. CFM-2 possesses anticonvulsant activity in various models of seizures.
    CFM-2 (Standard)
  • HY-125087
    A-304121 360551-71-9 98%
    A-304121 is a selective and brain penetrating H3 receptor antagonist. A-304121 is a cognition-enhancing agent.
    A-304121
  • HY-12515R
    Nicardipine (Standard) 55985-32-5 98%
    Nicardipine (Standard) is the analytical standard of Nicardipine. This product is intended for research and analytical applications. Nicardipine (YC-93 free base) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure.
    Nicardipine (Standard)
  • HY-12520C
    (S)-SKF 38393 81702-43-4 98%
    (S)-SKF 38393 is the S-enantiomer of SKF 38393 (HY-12520). (S)-SKF 38393 shows no activity against the D1 dopamine receptor, with an IC50 of 10700 nM. (S)-SKF 38393 can be used in the research of neurological diseases.
    (S)-SKF 38393
  • HY-125463
    ANQ9040 142021-80-5 98%
    ANQ9040 is a steroidal relaxant. ANQ9040 is a relatively low-affinity and non-depolarizing nicotinic antagonist.
    ANQ9040
  • HY-125508
    CCD-3693 162883-07-0 98%
    CCD-3693 is an orally active GABA receptor agonist. CCD-3693 has anxiolytic, anticonvulsant and sedative hypnotic activities and can be used in research related to neurological diseases.
    CCD-3693
  • HY-125602
    MNI-444 1974301-94-4 98%
    MNI-444 is a BBB-penetrable ligand of adenosine 2A receptor (A2AR). A2AR is a potential non-dopaminergic target for the research of Parkinson’s disease.
    MNI-444
Cat. No. Product Name / Synonyms Application Reactivity